Ontology highlight
ABSTRACT:
SUBMITTER: Jones ME
PROVIDER: S-EPMC2190753 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Jones Mary Elizabeth ME Zhuang Yuan Y
Immunity 20071201 6
The T cell receptor (TCR) is required for positive selection and the subsequent transition from the CD4(+)CD8(+) double-positive (DP) to the CD4(+) or CD8(+) single-positive (SP) stage of alphabeta T cell development. The molecular mechanism that maintains DP fate prior to the acquisition of a functional TCR is not clear. We have shown here that the structurally and functionally related transcription factors HEB and E2A work together to maintain DP fate and to control the DP to SP transition. Si ...[more]