Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC2193177 | biostudies-literature | 2000 Apr
REPOSITORIES: biostudies-literature
Liu Y Y Chirino A J AJ Misulovin Z Z Leteux C C Feizi T T Nussenzweig M C MC Bjorkman P J PJ
The Journal of experimental medicine 20000401 7
The macrophage and epithelial cell mannose receptor (MR) binds carbohydrates on foreign and host molecules. Two portions of MR recognize carbohydrates: tandemly arranged C-type lectin domains facilitate carbohydrate-dependent macrophage uptake of infectious organisms, and the NH(2)-terminal cysteine-rich domain (Cys-MR) binds to sulfated glycoproteins including pituitary hormones. To elucidate the mechanism of sulfated carbohydrate recognition, we determined crystal structures of Cys-MR alone an ...[more]