Ontology highlight
ABSTRACT:
SUBMITTER: Zhu G
PROVIDER: S-EPMC524345 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
Zhu Guangyu G Zhai Peng P He Xiangyuan X Wakeham Nancy N Rodgers Karla K Li Guangpu G Tang Jordan J Zhang Xuejun C XC
The EMBO journal 20040930 20
GGA proteins coordinate the intracellular trafficking of clathrin-coated vesicles through their interaction with several other proteins. The GAT domain of GGA proteins interacts with ARF, ubiquitin, and Rabaptin5. The GGA-Rabaptin5 interaction is believed to function in the fusion of trans-Golgi-derived vesicles to endosomes. We determined the crystal structure of a human GGA1 GAT domain fragment in complex with the Rabaptin5 GAT-binding domain. In this structure, the Rabaptin5 domain is a 90-re ...[more]