Ontology highlight
ABSTRACT:
SUBMITTER: Richard E
PROVIDER: S-EPMC2193361 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Richard E E Arredondo-Vega F X FX Santisteban I I Kelly S J SJ Patel D D DD Hershfield M S MS
The Journal of experimental medicine 20001101 9
Human, but not murine, adenosine deaminase (ADA) forms a complex with the cell membrane protein CD26/dipeptidyl peptidase IV. CD26-bound ADA has been postulated to regulate extracellular adenosine levels and to modulate the costimulatory function of CD26 on T lymphocytes. Absence of ADA-CD26 binding has been implicated in causing severe combined immunodeficiency due to ADA deficiency. Using human-mouse ADA hybrids and ADA point mutants, we have localized the amino acids critical for CD26 binding ...[more]