Ontology highlight
ABSTRACT:
SUBMITTER: Grunt TW
PROVIDER: S-EPMC4396035 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Grunt Thomas W TW Hebar Alexandra A Laffer Sylvia S Wagner Renate R Peter Barbara B Herrmann Harald H Graf Alexandra A Bilban Martin M Posch Martin M Hoermann Gregor G Mayerhofer Matthias M Eisenwort Gregor G Zielinski Christoph C CC Selzer Edgar E Valent Peter P
American journal of cancer research 20150115 2
Advanced colorectal cancer is characterized by uncontrolled growth and resistance against anti-cancer agents, including ErbB inhibitors. Recent data suggest that cancer stem cells (CSC) are particularly resistant. These cells may reside within a CD133+ fraction of the malignant cells. Using HCT116 cells we explored the role of CD133 and other CSC markers in drug resistance in colon cancer cells. CD133+ cells outnumbered CD133- cells over time in long-term culture. Both populations displayed the ...[more]