Neutral-lipid analysis reveals elevation of acylglycerols and lack of cholesterol esters in Plasmodium falciparum-infected erythrocytes.
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ABSTRACT:
SUBMITTER: Nawabi P
PROVIDER: S-EPMC219371 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
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Neutral-lipid analysis reveals elevation of acylglycerols and lack of cholesterol esters in Plasmodium falciparum-infected erythrocytes.
Nawabi Parwez P Lykidis Athanasios A Ji Darder D Haldar Kasturi K
Eukaryotic cell 20031001 5
Here we show that blood-stage Plasmodium falciparum organisms accumulate a high mass of triacylglycerol and diacylglycerol. However, we failed to detect cholesterol esters, a second neutral lipid species reported to be important for a related apicomplexan, Toxoplasma gondii. Evidence for P. falciparum and T. gondii homologues of acyl coenzyme A:diacylglycerol acyltransferase suggests that acylglycerols may be the conserved neutral lipids in apicomplexans. ...[more]
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