Ontology highlight
ABSTRACT:
SUBMITTER: Saulquin X
PROVIDER: S-EPMC2193886 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Saulquin Xavier X Gastinel Louis N LN Vivier Eric E
The Journal of experimental medicine 20030331 7
Killer cell Ig-like receptors (KIRs) regulate the function of human natural killer and T cell subsets. A feature of the KIR locus is the clustering of homologous genes encoding for inhibitory and activating KIR. Inhibitory and activating KIR differ for ligand specificities and/or affinities. In particular, we show here with KIR tetramers that activating KIR2DS2 does not bind HLA-Cw3 molecules recognized by inhibitory KIR2DL2, despite 99% extracellular amino acid identity. We also report the 2.3- ...[more]