Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.
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ABSTRACT:
SUBMITTER: Tomasec P
PROVIDER: S-EPMC2844263 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Publications
Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.
Tomasec Peter P Wang Eddie C Y EC Davison Andrew J AJ Vojtesek Borivoj B Armstrong Melanie M Griffin Cora C McSharry Brian P BP Morris Rebecca J RJ Llewellyn-Lacey Sian S Rickards Carole C Nomoto Akio A Sinzger Christian C Wilkinson Gavin W G GW
Nature immunology 20050109 2
Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus. UL141 mediated efficient protection of cells against killing by a wide range of human NK cell populations, including interferon-alpha-stimulated bulk cultures, polyclonal NK cell lines and most NK cell clones tested. Evasion of NK cell killing was ...[more]
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