Ontology highlight
ABSTRACT:
SUBMITTER: McDonald JP
PROVIDER: S-EPMC2194173 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
McDonald John P JP Frank Ekaterina G EG Plosky Brian S BS Rogozin Igor B IB Masutani Chikahide C Hanaoka Fumio F Woodgate Roger R Gearhart Patricia J PJ
The Journal of experimental medicine 20030801 4
Recent studies suggest that DNA polymerase eta (poleta) and DNA polymerase iota (poliota) are involved in somatic hypermutation of immunoglobulin variable genes. To test the role of poliota in generating mutations in an animal model, we first characterized the biochemical properties of murine poliota. Like its human counterpart, murine poliota is extremely error-prone when catalyzing synthesis on a variety of DNA templates in vitro. Interestingly, when filling in a 1 base-pair gap, DNA synthesis ...[more]