Ontology highlight
ABSTRACT:
SUBMITTER: Richter K
PROVIDER: S-EPMC3442519 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Richter Kathleen K Burch Lauranell L Chao Frank F Henke David D Jiang Chuancang C Daly Janssen J Zhao Ming-Lang ML Kissling Grace G Diaz Marilyn M
The Journal of biological chemistry 20120725 38
We recently identified a novel germinal center GTPase, SLIP-GC, that localizes to replication factories in B cells and that, when reduced, induces DNA breaks in lymphoma B cell lines in an activation-induced deaminase (AID)-dependent manner. Herein, we generated mice deficient in SLIP-GC and examined the impact of SLIP-GC deficiency in immunoglobulin hypermutation and class switch recombination, both AID-dependent mechanisms. SLIP-GC-deficient mice experienced a substantial increase in mutations ...[more]