Ontology highlight
ABSTRACT:
SUBMITTER: Bosma GC
PROVIDER: S-EPMC2194268 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20021201 11
Class switch recombination (CSR), similar to V(D)J recombination, is thought to involve DNA double strand breaks and repair by the nonhomologous end-joining pathway. A key component of this pathway is DNA-dependent protein kinase (DNA-PK), consisting of a catalytic subunit (DNA-PKcs) and a DNA-binding heterodimer (Ku70/80). To test whether DNA-PKcs activity is essential for CSR, we examined whether IgM(+) B cells from scid mice with site-directed H and L chain transgenes were able to undergo CSR ...[more]