Ontology highlight
ABSTRACT:
SUBMITTER: Di Virgilio M
PROVIDER: S-EPMC3815530 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Di Virgilio Michela M Callen Elsa E Yamane Arito A Zhang Wenzhu W Jankovic Mila M Gitlin Alexander D AD Feldhahn Niklas N Resch Wolfgang W Oliveira Thiago Y TY Chait Brian T BT Nussenzweig André A Casellas Rafael R Robbiani Davide F DF Nussenzweig Michel C MC
Science (New York, N.Y.) 20130110 6120
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to the loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its phosphorylation, but whether 53BP1 does so directly is not known. Here, we identify Rap1-interacting factor 1 (Rif1) as an ATM (ataxia-telangiectasia mutated) phosphorylation-dependent interactor of ...[more]