Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC2194628 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Li Wenwu W Sun Guoqiang G Yang Su S Qu Qiuhao Q Nakashima Kinichi K Shi Yanhong Y
Molecular endocrinology (Baltimore, Md.) 20070927 1
TLX is an orphan nuclear receptor that is expressed exclusively in vertebrate forebrains. Although TLX is known to be expressed in embryonic brains, the mechanism by which it influences neural development remains largely unknown. We show here that TLX is expressed specifically in periventricular neural stem cells in embryonic brains. Significant thinning of neocortex was observed in embryonic d 14.5 TLX-null brains with reduced nestin labeling and decreased cell proliferation in the germinal zon ...[more]