Ontology highlight
ABSTRACT:
SUBMITTER: Mackay F
PROVIDER: S-EPMC2195729 | biostudies-literature | 1999 Dec
REPOSITORIES: biostudies-literature
Mackay F F Woodcock S A SA Lawton P P Ambrose C C Baetscher M M Schneider P P Tschopp J J Browning J L JL
The Journal of experimental medicine 19991201 11
The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases. BAFF, a new member of the TNF family, binds to B cells and costimulates their growth in vitro. Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complex ...[more]