Ontology highlight
ABSTRACT:
SUBMITTER: De Martino M
PROVIDER: S-EPMC7184748 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
De Martino Marco M De Biase Davide D Forzati Floriana F Credendino Sara Carmela SC Palma Giuseppe G Barbieri Antonio A Arra Claudio C Paciello Orlando O Gaudio Eugenio E Ponzoni Maurilio M De Vita Gabriella G Chieffi Paolo P Bertoni Francesco F Fusco Alfredo A Esposito Francesco F
Scientific reports 20200427 1
We have recently identified and characterized two pseudogenes (HMGA1P6 and HMGA1P7) of the HMGA1 gene, which has a critical role in malignant cell transformation and cancer progression. HMGA1P6 and HMGAP17 act as microRNA decoy for HMGA1 and other cancer-related genes upregulating their protein levels. We have previously shown that they are upregulated in several human carcinomas, and their expression positively correlates with a poor prognosis and an advanced cancer stage. To evaluate in vivo o ...[more]