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Optimal design and validation of antiviral siRNA for targeting HIV-1.


ABSTRACT: We propose rational designing of antiviral short-interfering RNA (siRNA) targeting highly divergent HIV-1. In this study, conserved regions within HIV-1 genomes were identified through an exhaustive computational analysis, and the functionality of siRNAs targeting the highest possible conserved regions was validated. We present several promising antiviral siRNA candidates that effectively inhibited multiple subtypes of HIV-1 by targeting the best conserved regions in pandemic HIV-1 group M strains.

SUBMITTER: Naito Y 

PROVIDER: S-EPMC2204037 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature

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Optimal design and validation of antiviral siRNA for targeting HIV-1.

Naito Yuki Y   Nohtomi Kyoko K   Onogi Toshinari T   Uenishi Rie R   Ui-Tei Kumiko K   Saigo Kaoru K   Takebe Yutaka Y  

Retrovirology 20071108


We propose rational designing of antiviral short-interfering RNA (siRNA) targeting highly divergent HIV-1. In this study, conserved regions within HIV-1 genomes were identified through an exhaustive computational analysis, and the functionality of siRNAs targeting the highest possible conserved regions was validated. We present several promising antiviral siRNA candidates that effectively inhibited multiple subtypes of HIV-1 by targeting the best conserved regions in pandemic HIV-1 group M strai  ...[more]

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