Ontology highlight
ABSTRACT:
SUBMITTER: Mori Y
PROVIDER: S-EPMC2206117 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Mori Yasunori Y Higuchi Maiko M Hirabayashi Yusuke Y Fukuda Mitsunori M Gotoh Yukiko Y
The EMBO journal 20071129 1
Ca2+ influx induced by membrane depolarization triggers the exocytosis of secretory vesicles in various cell types such as endocrine cells and neurons. Peptidyl growth factors enhance Ca2+-evoked release, an effect that may underlie important adaptive responses such as the long-term potentiation of synaptic transmission induced by growth factors. Here, we show that activation of the c-Jun N-terminal kinase (JNK) plays an essential role in nerve growth factor (NGF) enhancement of Ca2+-evoked rele ...[more]