Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC2739891 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Xu Jun J Pang Zhiping P ZP Shin Ok-Ho OH Südhof Thomas C TC
Nature neuroscience 20090601 6
Spontaneous 'mini' release occurs at all synapses, but its nature remains enigmatic. We found that >95% of spontaneous release in murine cortical neurons was induced by Ca2+-binding to synaptotagmin-1 (Syt1), the Ca2+ sensor for fast synchronous neurotransmitter release. Thus, spontaneous and evoked release used the same Ca2+-dependent release mechanism. As a consequence, Syt1 mutations that altered its Ca2+ affinity altered spontaneous and evoked release correspondingly. Paradoxically, Syt1 del ...[more]