Ontology highlight
ABSTRACT:
SUBMITTER: Parnell TJ
PROVIDER: S-EPMC2206128 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Parnell Timothy J TJ Huff Jason T JT Cairns Bradley R BR
The EMBO journal 20071206 1
Nucleosomes can restrict the access of transcription factors to chromatin. RSC is a SWI/SNF-family chromatin-remodeling complex from yeast that repositions and ejects nucleosomes in vitro. Here, we examined these activities and their importance in vivo. We utilized array-based methods to examine nucleosome occupancy and positioning at more than 200 locations in the genome following the controlled destruction of the catalytic subunit of RSC, Sth1. Loss of RSC function caused pronounced and genera ...[more]