Ontology highlight
ABSTRACT:
SUBMITTER: Shin JY
PROVIDER: S-EPMC2206141 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Shin Jong-Yeon JY Fitzpatrick Galina V GV Higgins Michael J MJ
The EMBO journal 20071213 1
Imprinting control regions (ICRs) are known to repress genes by utilizing one of two mechanisms, CTCF-mediated insulation or the transcription of non-coding RNAs (ncRNAs). The KvDMR1 ICR contains both the promoter for the Kcnq1ot1 ncRNA and two CTCF-binding sites located within sequences exhibiting repressive activity in enhancer-blocking assays. Deletion of KvDMR1 results in ubiquitous biallelic expression of eight maternal-specific genes in distal chromosome 7. Here we report that while trunca ...[more]