Ontology highlight
ABSTRACT:
SUBMITTER: Jacq L
PROVIDER: S-EPMC2206364 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Jacq Laurent L Garnier Sophie S Dieudé Philippe P Michou Laëtitia L Pierlot Céline C Migliorini Paola P Balsa Alejandro A Westhovens René R Barrera Pilar P Alves Helena H Vaz Carlos C Fernandes Manuela M Pascual-Salcedo Dora D Bombardieri Stefano S Dequeker Jan J Radstake Timothy R TR Van Riel Piet P van de Putte Leo L Lopes-Vaz Antonio A Glikmans Elodie E Barbet Sandra S Lasbleiz Sandra S Lemaire Isabelle I Quillet Patrick P Hilliquin Pascal P Teixeira Vitor Hugo VH Petit-Teixeira Elisabeth E Mbarek Hamdi H Prum Bernard B Bardin Thomas T Cornélis François F
Arthritis research & therapy 20070101 4
The integrin alpha(v)beta3, whose alpha(v) subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the suggested RA susceptibility loci. Our aim was to test the ITGAV gene for association and linkage to RA in a family-based study from the European Caucasian population. Two single nucleotide polymorphisms were genotyped by PCR-restriction fragment length polymorphism in 100 Fre ...[more]