Ontology highlight
ABSTRACT:
SUBMITTER: Miller BG
PROVIDER: S-EPMC2206970 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20070901 9
Investigations of enzyme action typically focus on elucidating the catalytic roles of hydrogen bonding interactions between polar active-site residues and substrate molecules. Less clear is the importance of non-hydrogen bonding contacts to enzymatic rate accelerations. To investigate the importance of such interactions in a model system, six residues that participate in van der Waals contacts with substrate glucose within the active site of Escherichia coli glucokinase were individually randomi ...[more]