Ontology highlight
ABSTRACT:
SUBMITTER: Hulsmeyer M
PROVIDER: S-EPMC2211767 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Hülsmeyer Martin M Fiorillo Maria Teresa MT Bettosini Francesca F Sorrentino Rosa R Saenger Wolfram W Ziegler Andreas A Uchanska-Ziegler Barbara B
The Journal of experimental medicine 20040101 2
The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not. The subtypes also generate differential T cell repertoires as exemplified by distinct T cell responses against the self-peptide pVIPR (RRKWRRWHL). The crystal structures described here show th ...[more]