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Dual, HLA-B27 subtype-dependent conformation of a self-peptide.


ABSTRACT: The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not. The subtypes also generate differential T cell repertoires as exemplified by distinct T cell responses against the self-peptide pVIPR (RRKWRRWHL). The crystal structures described here show that pVIPR binds in an unprecedented dual conformation only to HLA-B*2705 molecules. In one binding mode, peptide pArg5 forms a salt bridge to Asp116, connected with drastically different interactions between peptide and heavy chain, contrasting with the second, conventional conformation, which is exclusively found in the case of B*2709. These subtype-dependent differences in pVIPR binding link the emergence of dissimilar T cell repertoires in individuals with HLA-B*2705 or HLA-B*2709 to the buried Asp116/His116 polymorphism and provide novel insights into peptide presentation by major histocompatibility antigens.

SUBMITTER: Hulsmeyer M 

PROVIDER: S-EPMC2211767 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature

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Dual, HLA-B27 subtype-dependent conformation of a self-peptide.

Hülsmeyer Martin M   Fiorillo Maria Teresa MT   Bettosini Francesca F   Sorrentino Rosa R   Saenger Wolfram W   Ziegler Andreas A   Uchanska-Ziegler Barbara B  

The Journal of experimental medicine 20040101 2


The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not. The subtypes also generate differential T cell repertoires as exemplified by distinct T cell responses against the self-peptide pVIPR (RRKWRRWHL). The crystal structures described here show th  ...[more]

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2009-07-17 | GSE11022 | GEO