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Inhibition of the B cell by CD22: a requirement for Lyn.

ABSTRACT: Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice.

SUBMITTER: Smith KG

PROVIDER: S-EPMC2212179 | biostudies-literature | 1998 Mar

REPOSITORIES: biostudies-literature

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Inhibition of the B cell by CD22: a requirement for Lyn.

Smith K G KG Tarlinton D M DM Doody G M GM Hibbs M L ML Fearon D T DT

The Journal of experimental medicine 19980301 5

Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice. ...[more]

PMID: 9480991

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