Ontology highlight
ABSTRACT:
SUBMITTER: Brown MH
PROVIDER: S-EPMC2212392 | biostudies-literature | 1998 Dec
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 19981201 11
2B4 is a cell surface glycoprotein related to CD2 and implicated in the regulation of natural killer and T lymphocyte function. A recombinant protein containing the extracellular region of mouse (m)2B4 attached to avidin-coated fluorescent beads bound to rodent cells, and binding was completely blocked by CD48 monoclonal antibodies (mAbs). Using surface plasmon resonance, we showed that purified soluble mCD48 bound m2B4 with a six- to ninefold higher affinity (Kd approximately 16 microM at 37 de ...[more]