Ontology highlight
ABSTRACT:
SUBMITTER: Velikovsky CA
PROVIDER: S-EPMC2519619 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Immunity 20071018 4
Natural killer (NK) cells eliminate virally infected and tumor cells. Among the receptors regulating NK cell function is 2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM) family that binds CD48. 2B4 is the only heterophilic receptor of the SLAM family, whose other members, e.g., NK-T-B-antigen (NTB-A), are self-ligands. We determined the structure of the complex between the N-terminal domains of mouse 2B4 and CD48, as well as the structures of unbound 2B4 and CD48. The ...[more]