Ontology highlight
ABSTRACT:
SUBMITTER: Barreto VM
PROVIDER: S-EPMC2212934 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Barreto Vasco M VM Pan-Hammarstrom Qiang Q Zhao Yaofeng Y Hammarstrom Lennart L Misulovin Ziva Z Nussenzweig Michel C MC
The Journal of experimental medicine 20050912 6
Class switch recombination was the last of the lymphocyte-specific DNA modification reactions to appear in the evolution of the adaptive immune system. It is absent in cartilaginous and bony fish, and it is common to all tetrapods. Class switching is initiated by activation-induced cytidine deaminase (AID), an enzyme expressed in cartilaginous and bony fish that is also required for somatic hypermutation. Fish AID differs from orthologs found in tetrapods in several respects, including its catal ...[more]