Ontology highlight
ABSTRACT:
SUBMITTER: Choi JE
PROVIDER: S-EPMC6920541 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Choi Jee Eun JE Matthews Allysia J AJ Michel Genesis G Vuong Bao Q BQ
Journal of immunology (Baltimore, Md. : 1950) 20191122 1
Activation-induced cytidine deaminase (AID) generates U:G mismatches in Ig genes that can be converted into untemplated mutations during somatic hypermutation or DNA double-strand breaks during class switch recombination (CSR). Null mutations in <i>UNG</i> and <i>MSH2</i> demonstrate the complementary roles of the base excision repair (BER) and mismatch repair pathways, respectively, in CSR. Phosphorylation of AID at serine 38 was previously hypothesized to regulate BER during CSR, as the AID ph ...[more]