Ontology highlight
ABSTRACT:
SUBMITTER: Lindqvist L
PROVIDER: S-EPMC2216682 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Lindqvist Lisa L Oberer Monika M Reibarkh Mikhail M Cencic Regina R Bordeleau Marie-Eve ME Vogt Emily E Marintchev Assen A Tanaka Junichi J Fagotto Francois F Altmann Michael M Wagner Gerhard G Pelletier Jerry J
PloS one 20080213 2
RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected helicases a challenging problem. The prototypical DEAD box RNA helicase, eIF4A, works in conjunction with other translation factors to prepare mRNA templates for ribosome recruitment during translation initiation. Herein, we provide insight into ...[more]