Defining subphenotypes for oral clefts based on dental development.
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ABSTRACT:
SUBMITTER: Letra A
PROVIDER: S-EPMC2222667 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Publications
Defining subphenotypes for oral clefts based on dental development.
Letra A A Menezes R R Granjeiro J M JM Vieira A R AR
Journal of dental research 20071001 10
Individuals with clefts present considerably more dental anomalies than do individuals without clefts. We used dental development to subphenotype clefts with the goal of identifying cleft subgroups that could have specific genetic contributions. We examined 1000 individuals, 500 with clefts and 500 without. We used several clinical features, such as cleft completeness or incompleteness, laterality, and the presence of dental anomalies to assess each individual's cleft status. We performed chi-sq ...[more]
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