Ontology highlight
ABSTRACT:
SUBMITTER: Kuchler EC
PROVIDER: S-EPMC5953560 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Küchler Erika Calvano EC Silva Lea Assed da LAD Nelson-Filho Paulo P Sabóia Ticiana M TM Rentschler Angela M AM Granjeiro José Mauro JM Oliveira Driely D Tannure Patricia N PN Silva Raquel Assed da RAD Antunes Leonardo Santos LS Tsang Michael M Vieira Alexandre R AR
Journal of applied oral science : revista FOB 20180521
Objectives To evaluate the association between hypoxia during embryo development and oral clefts in an animal model, and to evaluate the association between polymorphisms in the HIF-1A gene with oral clefts in human families. Material and Methods The study with the animal model used zebrafish embryos at 8 hours post-fertilization submitted to 30% and 50% hypoxia for 24 hours. At 5 days post-fertilization, the larvae were fixed. The cartilage structures were stained to evaluate craniofacial pheno ...[more]