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Analysis of toxigenic Corynebacterium ulcerans strains revealing potential for false-negative real-time PCR results.

ABSTRACT: Diphtheria surveillance depends on the rapid and reliable recognition of the toxin gene in Corynebacterium diphtheriae. Real-time PCR is a rapid tool to confirm the presence of the diphtheria toxin gene (tox) in an isolate or specimen. We report that some toxigenic Corynebacterium ulcerans strains show atypical results in a real-time PCR for tox.

SUBMITTER: Cassiday PK

PROVIDER: S-EPMC2224273 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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Analysis of toxigenic Corynebacterium ulcerans strains revealing potential for false-negative real-time PCR results.

Cassiday Pamela K PK Pawloski Lucia C LC Tiwari Tejpratap T Sanden Gary N GN Wilkins Patricia P PP

Journal of clinical microbiology 20071107 1

Diphtheria surveillance depends on the rapid and reliable recognition of the toxin gene in Corynebacterium diphtheriae. Real-time PCR is a rapid tool to confirm the presence of the diphtheria toxin gene (tox) in an isolate or specimen. We report that some toxigenic Corynebacterium ulcerans strains show atypical results in a real-time PCR for tox. ...[more]

PMID: 17989189

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