Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC2224587 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Zhang Xin X Green Todd J TJ Tsao Jun J Qiu Shihong S Luo Ming M
Journal of virology 20071114 2
The crystal structure of the vesicular stomatitis virus nucleoprotein (N) in complex with RNA reveals extensive and specific intermolecular interactions among the N molecules in the 10-member oligomer. What roles these interactions play in encapsidating RNA was studied by mutagenesis of the N protein. Three N mutants intended for disruption of the intermolecular interactions were designed and coexpressed with the phosphoprotein (P) in an Escherichia coli system previously described (T. J. Green ...[more]