Ontology highlight
ABSTRACT:
SUBMITTER: Price GA
PROVIDER: S-EPMC2225598 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Vaccine 20070806 41
We have previously demonstrated the full-length gonococcal transferrin binding proteins (TbpA and TbpB) to be promising antigens in the development of a protective vaccine against Neisseria gonorrhoeae. In the current study we employed a genetic chimera approach fusing domains from TbpA and TbpB to the A2 domain of cholera toxin, which naturally binds in a non-covalent fashion to the B subunit of cholera toxin during assembly. For one construct, the N-terminal half of TbpB (NB) was fused to the ...[more]