Ontology highlight
ABSTRACT:
SUBMITTER: Jewett MW
PROVIDER: S-EPMC2229028 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Jewett Mollie W MW Byram Rebecca R Bestor Aaron A Tilly Kit K Lawrence Kevin K Burtnick Mary N MN Gherardini Frank F Rosa Patricia A PA
Molecular microbiology 20071004 4
The genome of Borrelia burgdorferi is composed of one linear chromosome and approximately 20 linear and circular plasmids. Although some plasmids are required by B. burgdorferi in vivo, most plasmids are dispensable for growth in vitro. However, circular plasmid (cp) 26 is present in all natural isolates and has never been lost during in vitro growth. This plasmid carries ospC, which is critical for mammalian infection. We previously showed that cp26 encodes essential functions, including the te ...[more]