Ontology highlight
ABSTRACT:
SUBMITTER: Kontis KJ
PROVIDER: S-EPMC2229375 | biostudies-literature | 1997 Oct
REPOSITORIES: biostudies-literature
The Journal of general physiology 19971001 4
The role of the voltage sensor positive charges in the activation and deactivation gating of the rat brain IIA sodium channel was investigated by mutating the second and fourth conserved positive charges in the S4 segments of all four homologous domains. Both charge-neutralizing (by glutamine substitution) and -conserving mutations were constructed in a cDNA encoding the sodium channel alpha subunit that had fast inactivation removed by the incorporation of the IFMQ3 mutation in the III-IV linke ...[more]