Ontology highlight
ABSTRACT:
SUBMITTER: Lacroix JJ
PROVIDER: S-EPMC4024920 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Lacroix Jérôme J JJ Hyde H Clark HC Campos Fabiana V FV Bezanilla Francisco F
Proceedings of the National Academy of Sciences of the United States of America 20140429 19
Voltage sensor domains (VSDs) regulate ion channels and enzymes by transporting electrically charged residues across a hydrophobic VSD constriction called the gating pore or hydrophobic plug. How the gating pore controls the gating charge movement presently remains debated. Here, using saturation mutagenesis and detailed analysis of gating currents from gating pore mutations in the Shaker Kv channel, we identified statistically highly significant correlations between VSD function and physicochem ...[more]