Ontology highlight
ABSTRACT:
SUBMITTER: Daria D
PROVIDER: S-EPMC2234042 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Daria Deidre D Filippi Marie-Dominique MD Knudsen Erik S ES Faccio Roberta R Li Zhixiong Z Kalfa Theodosia T Geiger Hartmut H
Blood 20071129 4
The retinoblastoma tumor suppressor protein (RB) plays important roles in the control of the cell division cycle. It is estimated that RB is dysfunctional/inactivated in up to 40% of human leukemias. The consequences of loss of RB on hematopoietic stem and progenitor cell (HSPC) function in vivo are incompletely understood. Here, we report that mice genetically deficient in Rb in all hematopoietic cells (Vav-Cre Rb knockout [KO] animals) showed altered contribution of distinct hematopoietic cell ...[more]