Ontology highlight
ABSTRACT:
SUBMITTER: Tortola L
PROVIDER: S-EPMC4893156 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Cell reports 20160505 7
The HECT domain E3 ligase HACE1 has been identified as a tumor suppressor in multiple cancers. Here, we report that HACE1 is a central gatekeeper of TNFR1-induced cell fate. Genetic inactivation of HACE1 inhibits TNF-stimulated NF-κB activation and TNFR1-NF-κB-dependent pathogen clearance in vivo. Moreover, TNF-induced apoptosis was impaired in hace1 mutant cells and knockout mice in vivo. Mechanistically, HACE1 is essential for the ubiquitylation of the adaptor protein TRAF2 and formation of th ...[more]