Gene alteration and precursor and mature microRNA transcription changes contribute to the miRNA signature of primary effusion lymphoma.
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ABSTRACT:
SUBMITTER: O'Hara AJ
PROVIDER: S-EPMC2234063 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Publications
Gene alteration and precursor and mature microRNA transcription changes contribute to the miRNA signature of primary effusion lymphoma.
O'Hara Andrea J AJ Vahrson Wolfgang W Dittmer Dirk P DP
Blood 20071213 4
MicroRNAs are regulated by gene alteration, transcription, and processing. Thus far, few studies have simultaneously assessed all 3 levels of regulation. Using real-time quantitative polymerase chain reaction (QPCR)-based arrays, we determined changes in gene copy number, pre-miRNA, and mature miRNA levels for the largest set of primary effusion lymphomas (PELs) to date. We detected PEL-specific miRNA gene amplifications, and concordant changes in pre-miRNA and mature miRNA. We identified 68 PEL ...[more]
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