Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC6368210 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Yang Fan F Cheng Yaru Y Cao Yu Y Dong Haifeng H Lu Huiting H Zhang Kai K Meng Xiangdan X Liu Conghui C Zhang Xueji X
Chemical science 20181128 6
Mature microRNAs (miRNAs) produced from precursor microRNAs (pre-miRNAs) by the RNase Dicer have showed significant potential for cancer diagnosis and prognosis due to their key regulatory roles in various pathological processes. However, discriminatory detection of low-abundance miRNAs and pre-miRNAs remains a key challenge since the mature sequence is also present in the pre-miRNA forms. Herein, we report a novel cascade reaction to sensitively distinguish miRNAs <i>versus</i> pre-miRNAs in li ...[more]