Ontology highlight
ABSTRACT:
SUBMITTER: Desai S
PROVIDER: S-EPMC2238176 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Desai Shailey S Loomis Zoe Z Pugh-Bernard Aimee A Schrunk Jessica J Doyle Michelle J MJ Minic Angela A McCoy Erica E Sussel Lori L
Developmental biology 20071003 1
Nkx2.2 is a homeodomain-containing transcription factor essential for pancreatic islet cell specification. In this study we investigate the role of Nkx2.2 within the small intestine. We have determined that Nkx2.2 is expressed at the onset of intestinal epithelial cell differentiation in specific intestinal cell populations, including a subset of enteroendocrine cells. Similar to its role in the pancreatic islet, Nkx2.2 regulates cell fate choices within the intestinal enteroendocrine population ...[more]