Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model.
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ABSTRACT:
SUBMITTER: Martin FP
PROVIDER: S-EPMC2238715 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model.
Martin Francois-Pierre J FP Wang Yulan Y Sprenger Norbert N Yap Ivan K S IK Lundstedt Torbjörn T Lek Per P Rezzi Serge S Ramadan Ziad Z van Bladeren Peter P Fay Laurent B LB Kochhar Sunil S Lindon John C JC Holmes Elaine E Nicholson Jeremy K JK
Molecular systems biology 20080115
The transgenomic metabolic effects of exposure to either Lactobacillus paracasei or Lactobacillus rhamnosus probiotics have been measured and mapped in humanized extended genome mice (germ-free mice colonized with human baby flora). Statistical analysis of the compartmental fluctuations in diverse metabolic compartments, including biofluids, tissue and cecal short-chain fatty acids (SCFAs) in relation to microbial population modulation generated a novel top-down systems biology view of the host ...[more]
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