Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children.
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ABSTRACT:
SUBMITTER: Martin FP
PROVIDER: S-EPMC5449421 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children.
Martin Francois-Pierre FP Su Ming-Ming MM Xie Guo-Xiang GX Guiraud Seu Ping SP Kussmann Martin M Godin Jean-Philippe JP Jia Wei W Nydegger Andreas A
World journal of gastroenterology 20170501 20
<h4>Aim</h4>To identify metabolic signatures in urine samples from healthy and inflammatory bowel disease (IBD) children.<h4>Methods</h4>We applied liquid chromatography and gas chromatography coupled to targeted mass spectrometry (MS)-based metabolite profiling to identify and quantify bile acids and host-gut microbial metabolites in urine samples collected from 21 pediatric IBD patients monitored three times over one year (baseline, 6 and 12 mo), and 27 age- and gender-matched healthy children ...[more]
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