Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions.
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ABSTRACT:
SUBMITTER: Lich JD
PROVIDER: S-EPMC2238720 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Publications
Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions.
Lich John D JD Ting Jenny Pan-Yun JP
Microbes and infection 20070127 5
CATERPILLER is a mammalian gene family with signature NBD and LRR domains. Several members of this family are positive regulators of inflammatory responses. Others, however, exert negative effects on proinflammatory responses. These data are particularly convincing when shRNA/siRNA are used. This review focuses on the Monarch-1/PYPAF7 gene with brief discussions of CLR16.2/NOD3, PYPAF2/PAN1/NALP2, and PYPAF3. ...[more]
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