Doxazosin induces apoptosis of cells expressing hERG K+ channels.
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ABSTRACT:
SUBMITTER: Thomas D
PROVIDER: S-EPMC2239015 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
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Doxazosin induces apoptosis of cells expressing hERG K+ channels.
Thomas Dierk D Bloehs Ramona R Koschny Ronald R Ficker Eckhard E Sykora Jaromir J Kiehn Johann J Schlömer Kathrin K Gierten Jakob J Kathöfer Sven S Zitron Edgar E Scholz Eberhard P EP Kiesecker Claudia C Katus Hugo A HA Karle Christoph A CA
European journal of pharmacology 20071204 1-3
The antihypertensive drug doxazosin has been associated with an increased risk for congestive heart failure and cardiomyocyte apoptosis. Human ether-a-go-go-related gene (hERG) K(+) channels, previously shown to be blocked by doxazosin at therapeutically relevant concentrations, represent plasma membrane receptors for the antihypertensive drug. To elucidate the molecular basis for doxazosin-associated pro-apoptotic effects, cell death was studied in human embryonic kidney cells using three indep ...[more]
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