Ontology highlight
ABSTRACT:
SUBMITTER: Popp D
PROVIDER: S-EPMC2241650 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Popp David D Narita Akihiro A Oda Toshiro T Fujisawa Tetsuro T Matsuo Hiroshi H Nitanai Yasushi Y Iwasa Mitsusada M Maeda Kayo K Onishi Hirofumi H Maéda Yuichiro Y
The EMBO journal 20080110 3
ParM is a prokaryotic actin homologue, which ensures even plasmid segregation before bacterial cell division. In vivo, ParM forms a labile filament bundle that is reminiscent of the more complex spindle formed by microtubules partitioning chromosomes in eukaryotic cells. However, little is known about the underlying structural mechanism of DNA segregation by ParM filaments and the accompanying dynamic instability. Our biochemical, TIRF microscopy and high-pressure SAX observations indicate that ...[more]