Ontology highlight
ABSTRACT:
SUBMITTER: Kidoya H
PROVIDER: S-EPMC2241654 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Kidoya Hiroyasu H Ueno Masaya M Yamada Yoshihiro Y Mochizuki Naoki N Nakata Mitsugu M Yano Takashi T Fujii Ryo R Takakura Nobuyuki N
The EMBO journal 20080117 3
Blood vessels change their caliber to adapt to the demands of tissues or organs for oxygen and nutrients. This event is mainly organized at the capillary level and requires a size-sensing mechanism. However, the molecular regulatory mechanism involved in caliber size modification in blood vessels is not clear. Here we show that apelin, a protein secreted from endothelial cells under the activation of Tie2 receptor tyrosine kinase on endothelial cells, plays a role in the regulation of caliber si ...[more]