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The Apelin/APJ System in Psychosis and Neuropathy.

ABSTRACT: Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The present article reviews the progress of the latest research investigating the apelin/APJ system in pain, depression, anxiety, memory, epilepsy, neuroprotection, stroke, and brain injury and protection, and highlights its promising potential as a therapeutic target for treatment of psychosis and neuropathy.

SUBMITTER: Lv SY

PROVIDER: S-EPMC7082832 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The Apelin/APJ System in Psychosis and Neuropathy.

Lv Shuang-Yu SY Chen Wei-Dong WD Wang Yan-Dong YD

Frontiers in pharmacology 20200313

Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The present article reviews the progress of the latest research investigating the apelin/APJ system in pain, depression, anxiety, memory, epilepsy, neu ...[more]

PMID: 32231577

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Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system.

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