Ontology highlight
ABSTRACT:
SUBMITTER: Barth S
PROVIDER: S-EPMC2241876 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Barth Stephanie S Pfuhl Thorsten T Mamiani Alfredo A Ehses Claudia C Roemer Klaus K Kremmer Elisabeth E Jäker Christoph C Höck Julia J Meister Gunter G Grässer Friedrich A FA
Nucleic acids research 20071210 2
MicroRNAs (miRNAs) have been implicated in sequence-specific cleavage, translational repression or deadenylation of specific target mRNAs resulting in post-transcriptional gene silencing. Epstein-Barr virus (EBV) encodes 23 miRNAs of unknown function. Here we show that the EBV-encoded miRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. MiR-BART2 guides cleavage within the 3'-untranslated region (3'UTR) of BALF5 by virtue of its complete complementarity to its target. Induction of the ...[more]